ve artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial
نویسندگان
چکیده
Médecins sans Frontières— Holland, Yangon, Myanmar (F Smithuis MD, M Kyaw Kyaw MBBS, O Phe BSc, T Win MBBS, P P Aung MBBS, A P P Oo MBBS, A L Naing MBBS, M Y Nyo MBBS, N Z H Myint MBBS); Medical Action Myanmar, Yangon, Myanmar (F Smithuis, O Phe); Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand (M Imwong PhD, E Ashley MRCP, S J Lee PhD, Prof N J White FRS); and Centre for Tropical Medicine, Nuffi eld Department of Clinical Medicine, Churchill Hospital, Oxford, UK (E Ashley, S J Lee, Prof N J White)
منابع مشابه
Study protocol for a randomised controlled double-blinded trial of the dose-dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda
OBJECTIVES For the purpose of blocking transmission of Plasmodium falciparum malaria from humans to mosquitoes, a single dose of primaquine is recommended by the WHO as an addition to artemisinin combination therapy. Primaquine clears gametocytes but causes dose-dependent haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Evidence is needed to inform the optimal...
متن کاملThe effect of primaquine on gametocyte development and clearance in the treatment of uncomplicated falciparum malaria with dihydroartemisinin-piperaquine in South sumatra, Western indonesia: an open-label, randomized, controlled trial.
BACKGROUND Artemisinin-based combination therapy is very effective in clearing asexual stages of malaria and reduces gametocytemia, but may not affect mature gametocytes. Primaquine is the only commercially available drug that eliminates mature gametocytes. METHODS We conducted a 2-arm, open-label, randomized, controlled trial to evaluate the efficacy of single-dose primaquine (0.75 mg/kg) fo...
متن کاملRandomised controlled trial of two sequential artemisinin-based combination therapy regimens to treat uncomplicated falciparum malaria in African children: a protocol to investigate safety, efficacy and adherence
BACKGROUND Management of uncomplicated Plasmodium falciparum malaria relies on artemisinin-based combination therapies (ACTs). These highly effective regimens have contributed to reductions in malaria morbidity and mortality. However, artemisinin resistance in Asia and changing parasite susceptibility to ACT in Africa have now been well documented. Strategies that retain current ACT as efficaci...
متن کاملEffectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial
BACKGROUND Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout the world, and fixed-dose combinations are preferred by WHO; whether a single gametocytocidal dose of primaquine should be added is unknown. We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the a...
متن کاملSingle dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission in Cambodia: An open-label randomized trial
BACKGROUND Single low dose primaquine (SLD PQ, 0.25mg/kg) is recommended in combination with artemisinin-based combination therapy (ACT) as a gametocytocide to prevent Plasmodium falciparum transmission in areas threatened by artemisinin resistance. To date, no randomized controlled trials have measured primaquine's effect on infectiousness to Anopheline mosquitoes in Southeast Asia. METHODS ...
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تاریخ انتشار 2010